Mucosal Delivery of IL-27 Attenuates Murine Enterocolitis via T Cell-Derived IL-10

Regulatory T cell-derived IL-10 ameliorates crescentic GN.

Regulatory T cells (Tregs) exert their immunosuppressive activity through several immunoregulatory mechanisms, including the production of anti-inflammatory cytokines such as IL-10. Although several studies suggest a role for Tregs in modulating crescentic GN, the underlying mechanisms are not well understood. Here, using IL-10 reporter mice, we detected IL-10-producing Foxp3(+) T cells in the ...

Leishmaniasis IL-10 Responses in Human Visceral IL-27 and IL-21 Are Associated with T Cell

IL-10 but Not FoxP3 in Murine T Cells Cutting Edge: IL-27 Is a Potent Inducer of

CD4+ T Cell-derived IL-10 Promotes Brucella abortus Persistence via Modulation of Macrophage Function

Evasion of host immune responses is a prerequisite for chronic bacterial diseases; however, the underlying mechanisms are not fully understood. Here, we show that the persistent intracellular pathogen Brucella abortus prevents immune activation of macrophages by inducing CD4(+)CD25(+) T cells to produce the anti-inflammatory cytokine interleukin-10 (IL-10) early during infection. IL-10 receptor...

IL-27 Promotes IL-10 Production by Effector